Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene
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چکیده
منابع مشابه
Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene.
Hypoxia promotes genetic instability and is therefore an important factor in carcinogenesis. We have previously shown that activation of the hypoxia responsive transcription factor HIFα can enhance the mutagenic phenotype induced by the environmental mutagen benzo[a]pyrene (BaP). To further elucidate the mechanism behind the ability of hypoxia to increase mutagenicity of carcinogens, we examine...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2014
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/geu034